Research in Maxillofacial Surgery

Mr Heliotis has been involved in researching tissue engineering techniques together with other colleagues in the international arena for many years. This background has allowed him to translate laboratory research into surgical practice, carrying out pioneering work in bone regeneration in patients. The bone grafting techniques that he uses for dental implant work, sinus lifts, periodontal structures and reconstruction of jaws, trauma and orthognathic surgery are therefore founded on solid scientific knowledge that he has helped develop, as attested by the scientific peer reviewed publications listed below. He has presented talks in many international medical and scientific conferences on tissue regeneration and is Specialty Lead in North West London for the National Institute for Health Research Clinical Research Network Coordinating Centre (NIHR CRN CC).

1.  Heliotis M and Ripamonti U. Phenotypic modulation of endothelial cells by bone morphogenetic proteins in vitro. In Vitro Cell. Dev. Biol. 1994; 30A: 353-355

2.  Ripamonti U, Heliotis M, van den Heever B and Reddi AH. Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio Ursinus). J. Periodont. Res. 1994; 29: 439-445

3.  Ripamonti U, Heliotis M, Rueger DC and Sampath TK. Induction of cementogenesis by recombinant human osteogenic protein-1 (hOP-1/BMP-7) in the baboon (Papio Ursinus). Arch. Oral Biol. 1996; 41(1): 121-126

5.  Donell S and Heliotis M. Bone Glues - The Fracture Fixation of the Future. Action For Biomaterials 1999; 2: 12

6.  Heliotis M and Tsiridis E. Fresh Frozen Bone in Femoral Impaction Grafting: Can Developments in Bone Regeneration Improve on This? Med. Hypoth. 2001; 57(6): 675-678

7.  Heliotis M, Tsiridis E, Donell TS, Marshall JT and Scott GD. Bilateral osteonecrosis of the tarsus coincident with glioblastoma multiforme. Journal of the Royal Society of Medicine 2001; 94: 635-636

8.  Ripamonti U, van den Heever B, Heliotis M, Dal Mas I, Hahnle UR and Biscardi A. Local delivery of bone morphogenetic proteins in primates using a reconstituted basement membrane gel: tissue engineering with Matrigel. S. Afr. J. Sci. 2002; 98:429-433

9.  Tsiridis E, Tsapaki E M, Heliotis M, Donell TS, Scott GD. Increased levels of tissue endostatin in human malignant gliomas. Letter to the editor. Clin. Cancer Res. 2004; 10:324-325

10. Head, Neck and Dental Emergencies. Contributing author. Editor: M. Perry. Oxford University Press 2005

11. Visavadia BV, Heliotis M, Sneddon KJ, Lavery KM, Brown AE. Sagittal split osteotomy for the correction of mandibular asymmetry and malocclusion following reconstruction of the mandible with free deep circumflex iliac artery flap. British Journal of Oral and Maxillofacial Surgery 2005; 43: 65-67

12. Heliotis M, Lavery KM, Ripamonti U, Tsiridis E, DiSilvio L. Transformation of a pre-fabricated hydroxyapatite/OP-1 implant into a vascularised pedicled bone flap in the human chest. International Journal of Oral and Maxillofacial Surgery 2006; 35(3): 265-269. Epub 2005 Oct 28

13. Ripamonti U, Ferreti C, Heliotis M. Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development. J. Anat. 2006; 209(4):447-68

14. Tsiridis E, Bhalla A, Zubier A, Gurav N, Heliotis M, Sanjukta D, DiSilvio L. Enhancing the osteoinductive properties of hydroxyapatite by the addition of human mesenchymal stem cells and recombinant human osteogenic protein-1 (BMP-7) in vitro Injury 2006; 37(3S):S25-S32

15. Tsiridis E, Ali Z, Bhalla A, Heliotis M, Gurav N, Deb S, DiSilvio L. In vitro and in vivo optimisation of impaction allografting by demineralisation and addition of rh-OP-1. J Orthop Res 2007; 25(11):1425-37

16. Ripamonti U, Heliotis M, Ferretti C. Bone morphogenetic Proteins and the Induction of Bone Formation: From Laboratory to Patients. Oral Maxillofacial Surg Clin N Am 2007; 19:575-589

17. Heliotis M, Messiha A. Augmentation mentoplasty with diced high-density porous polyethylene. Plast Reconstr Surg 2007; 120(6): 1740-1741

18. Heliotis M, Tsiridis E. Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation; therapeutic implications. Arthritis Res. Ther. 2008; 10(4): 115

19. Tsiridis E, Ali Z, Bhalla A, Gamie Z, Heliotis M, Gurav N, Deb S, DiSilvio L. In vitro proliferation and differentiation of human mesenchymal stem cells on hydroxyapatite versus human demineralised bone matrix with and without osteogenic protein-1. Expert Opin. Biol. Ther. 2009; 9(1): 9-19.

20. Tsialogiannis E, Polyzois I, Oak Tang Q, Pavlou G, Tsiridis E, Heliotis M, Tsiridis E. Targeting bone morphogenetic protein antagonists: in vitro and in vivo evidence of their role in bone metabolism. Expert Opin. Ther. Targets 2009; 13(1): 123-37. Review

21. Heliotis M, Ripamonti U, Ferretti C, Kerawala C, Mantalaris A, Tsiridis E. The basic science of bone induction. Br. J. Oral Maxillofac. Surg. 2009