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Research in Maxillofacial Surgery


Mr Heliotis has been involved in researching tissue engineering techniques together with other colleagues in the international arena for many years. This background has allowed him to translate laboratory research into surgical practice, carrying out pioneering work in bone regeneration in patients. The bone grafting techniques that he uses for dental implant work, sinus lifts, periodontal structures and reconstruction of jaws, trauma and orthognathic surgery are therefore founded on solid scientific knowledge that he has helped develop, as attested by the scientific peer reviewed publications listed below. He has presented talks in many international medical and scientific conferences on tissue regeneration.


1.  Heliotis M and Ripamonti U. Phenotypic modulation of endothelial cells by bone morphogenetic proteins in vitro. In Vitro Cell. Dev. Biol. 1994; 30A: 353-355


2. Ripamonti U, Heliotis M, van den Heever B and Reddi AH. Bone morphogenetic proteins induce periodontal regeneration in the baboon (Papio Ursinus). J. Periodont. Res. 1994; 29: 439-445


3.  Ripamonti U, Heliotis M, Rueger DC and Sampath TK. Induction of cementogenesis by recombinant human osteogenic protein-1 (hOP-1/BMP-7) in the baboon (Papio Ursinus). Arch. Oral Biol. 1996; 41(1): 121-126


5.  Donell S and Heliotis M. Bone Glues - The Fracture Fixation of the Future. Action For Biomaterials 1999; 2: 12


6.  Heliotis M and Tsiridis E. Fresh Frozen Bone in Femoral Impaction Grafting: Can Developments in Bone Regeneration Improve on This? Med. Hypoth. 2001; 57(6): 675-678


7. Heliotis M, Tsiridis E, Donell TS, Marshall JT and Scott GD. Bilateral osteonecrosis of the tarsus coincident with glioblastoma multiforme. Journal of the Royal Society of Medicine 2001; 94: 635-636


8.  Ripamonti U, van den Heever B, Heliotis M, Dal Mas I, Hahnle UR and Biscardi A. Local delivery of bone morphogenetic proteins in primates using a reconstituted basement membrane gel: tissue engineering with Matrigel. S. Afr. J. Sci. 2002; 98:429-433


9. Tsiridis E, Tsapaki E M, Heliotis M, Donell TS, Scott GD. Increased levels of tissue endostatin in human malignant gliomas. Letter to the editor. Clin. Cancer Res. 2004; 10:324-325


10. Head, Neck and Dental Emergencies. Contributing author. Editor: M. Perry. Oxford University Press 2005


11. Visavadia BG, Heliotis M, Sneddon KJ, Lavery KM, Brown AE. Sagittal split osteotomy of a vascularised iliac crest free flap to correct residual asymmetry and malocclusion in the reconstructed mandible. Br J Oral Maxillofac Surg. 2005 Feb;43(1):65-7


12. Heliotis M, Lavery KM, Ripamonti U, Tsiridis E, DiSilvio L. Transformation of a prefabricated hydroxyapatite/osteogenic protein-1 implant into a vascularised pedicled bone flap in the human chest. International Journal of Oral and Maxillofacial Surgery 2006; 35(3): 265-269.


13. Ripamonti U, Ferreti C, Heliotis M. Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development. J. Anat. 2006; 209(4):447-68


14. Tsiridis E, Bhalla A, Zubier A, Gurav N, Heliotis M, Sanjukta D, DiSilvio L. Enhancing the osteoinductive properties of hydroxyapatite by the addition of human mesenchymal stem cells and recombinant human osteogenic protein-1 (BMP-7) in vitro Injury 2006; 37(3S):S25-S32


15. Heliotis M. Misinformation. Br Dent J. 2006 Mar 25;200(6):303


16. Cameron M, Visavadia B, Heliotis M, Shelley M, Cascarini L, Kumar M, Fan K, Mills C, Swinson B, Hodges S, Bridle C, Walsh S, Leiw C, Coombes D, Shah N, Norris P, McKenzie J, Collyer J, Antscherl J, Bisase B, Chin-Shong D. OMFS training revisited. Br Dent J. 2006 Apr 8;200(7):361-2


17. Tsiridis E, Ali Z, Bhalla A, Heliotis M, Gurav N, Deb S, DiSilvio L. In vitro and in vivo optimisation of impaction allografting by demineralisation and addition of rh-OP-1. J Orthop Res 2007; 25(11):1425-37


18. Ripamonti U, Heliotis M, Ferretti C. Bone morphogenetic Proteins and the Induction of Bone Formation: From Laboratory to Patients. Oral Maxillofacial Surg Clin N Am 2007; 19:575-589


19. Heliotis M, Messiha A. Augmentation mentoplasty with diced high-density porous polyethylene. Plast Reconstr Surg 2007; 120(6): 1740-1741


20. Heliotis M, Tsiridis E. Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation; therapeutic implications. Arthritis Res. Ther. 2008; 10(4): 115


21. Tsiridis E, Ali Z, Bhalla A, Gamie Z, Heliotis M, Gurav N, Deb S, DiSilvio L. In vitro proliferation and differentiation of human mesenchymal stem cells on hydroxyapatite versus human demineralised bone matrix with and without osteogenic protein-1. Expert Opin. Biol. Ther. 2009; 9(1): 9-19.


22. Tsialogiannis E, Polyzois I, Oak Tang Q, Pavlou G, Tsiridis E, Heliotis M, Tsiridis E. Targeting bone morphogenetic protein antagonists: in vitro and in vivo evidence of their role in bone metabolism. Expert Opin. Ther. Targets 2009; 13(1): 123-37. Review


23. Heliotis M, Ripamonti U, Ferretti C, Kerawala C, Mantalaris A, Tsiridis E. The basic science of bone induction. Br. J. Oral Maxillofac. Surg.Review. 2009 Oct;47(7):511-4


24. Tang QO, Shakib K, Heliotis M, Tsiridis E, Mantalaris A, Ripamonti U, Tsiridis E. TGF-beta3: A potential biological therapy for enhancing chondrogenesis. Expert Opin Biol Ther. Review. 2009 Jun;9(6):689-701


25. Tran GT, Pagkalos J, Tsiridis E, Narvani AA, Heliotis M, Mantalaris A, Tsiridis E. Growth hormone: does it have a therapeutic role in fracture healing? Expert Opin Investig Drugs 2009 Jul;18(7):887-911


26. Shakib K, Heliotis M, Gilhooly M. The nasopharyngeal airway: reliable and effective tool for marsupialisation. Br J Oral Maxillofac Surg. 2010 Jul;48(5):386-7


27. Graham S, Leonidou A, Lester M, Heliotis M, Mantalaris A, Tsiridis E. 19. Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing. Expert Opin Investig Drugs. 2009 Nov;18(11):1633-54


28. Messiha A, Chadha A, Al-Hadad I, Hussain Z, Heliotis M. A survey of self-assessed surgical competencies with respect to qualifications, training and working patterns of members on the oral surgery register. Br Dent J. 2010 Jan 23;208(2):65-9


29. Graham SM, Leonidou A, Aslam-Pervez N, Hamza A, Panteliadis P, Heliotis M, Mantalaris A, Tsiridis E. Biological therapy of bone defects: the immunology of bone allo-transplantation. Expert Opin Biol Ther. 2010 Jun;10(6):885-901


30. Ferretti C, Ripamonti U, Tsiridis E, Kerawala CJ, Mantalaris A, Heliotis M. Osteoinduction: translating preclinical promise into clinical reality. Br J Oral Maxillofac Surg. 2010 Oct;48(7):536-9


31. Pagkalos J, Cha JM, Kang Y, Heliotis M, Tsiridis E, Mantalaris A. Simvastatin induces osteogenic differentiation of murine embryonic stem cells. J Bone Miner Res. 2010 Nov;25(11):2470-8


32. Ripamonti U, Tsiridis E, Ferretti C, Kerawala CJ, Mantalaris A, Heliotis M. Perspectives in regenerative medicine and tissue engineering of bone. Br J Oral Maxillofac Surg. 2011 Oct;49(7):507-9


33. Graham SM, Howgate D, Anderson W, Howes C, Heliotis M, Mantalaris A, Tsiridis E, Tsapakis E. Risk of osteoporosis and fracture incidence in patients on antipsychotic medication. Expert Opin Drug Saf. 2011 Jul;10(4):575-602


34. Pagkalos J, Leonidou A, As-Sultany M, Heliotis M, Mantalaris A, Tsiridis E. Prostaglandin E(2) receptors as potential bone anabolic targets - selective EP4 receptor agonists. Curr Mol Pharmacol. 2012 Jun;5(2):174-81


35. Borumandi F, Heliotis M, Kerawala C, Bisase B, Cascarini L. Role of robotic surgery in oral and maxillofacial, and head and neck surgery. Br J Oral Maxillofac Surg. 2012 Jul;50(5):389-93


36. Kallala R, Graham SM, Nikkhah D, Kyrkos M, Heliotis M, Mantalaris A, Tsiridis E. In vitro and in vivo effects of antibiotics on bone cell metabolism and fracture healing. Expert Opin Drug Saf. 2012 Jan;11(1):15-32


37. Gamie Z, Tran GT, Vyzas G, Korres N, Heliotis M, Mantalaris A, Tsiridis E. Stem cells combined with bone graft substitutes in skeletal tissue engineering. Expert Opin Biol Ther. 2012 Jun;12(6):713-29


38. MacFarlane RJ, Graham SM, Davies PS, Korres N, Tsouchnica H, Heliotis M, Mantalaris A, Tsiridis E. Anti-inflammatory role and immunomodulation of mesenchymal stem cells in systemic joint diseases: potential for treatment. Expert Opin Ther Targets. 2013 Mar;17(3):243-54


39. Kassam K, Messiha A, Heliotis M. Ludwig's Angina: The Original Angina. Case Rep Surg. 2013;2013:974269


40. Thavarajah M, Szamocki S, Komath D, Cascarini L, Heliotis M. Comparing disciplines: outcomes of non melanoma cutaneous malignant lesions in oral and maxillofacial surgery and dermatology. Eur J Surg Oncol. 2015 Jan;41(1):169-73


41. Klontzas ME, Kenanidis EI, Heliotis M, Tsiridis E, Mantalaris A. Bone and cartilage regeneration with the use of umbilical cord mesenchymal stem cells. Expert Opin Biol Ther. 2015;15(11):1541-52


42. Rahim I, Salt S, Heliotis M. Successful long-term mandibular reconstruction and rehabilitation using non-vascularised autologous bone graft and recombinant human BMP-7 with subsequent endosseous implant in a patient with bisphosphonate-related osteonecrosis of the jaw. Br J Oral Maxillofac Surg. 2015 Nov;53(9):870-4


43. Berridge N, Heliotis M. A Novel Technique for Improving Lower Facial Contour Using a 3-D Custom-Made Silicone Guide. Plast Reconstr Surg. 2015 Oct;136(4 Suppl):102


44. Kang Y, Georgiou AI, MacFarlane RJ, Klontzas ME, Heliotis M, Tsiridis E, Mantalaris A. Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells. J Tissue Eng Regen Med. 2015 Oct 9


45. Klontzas ME, Kenanidis EI, MacFarlane RJ, Michail T, Potoupnis ME, Heliotis M, Mantalaris A, Tsiridis E. Investigational drugs for fracture healing: preclinical & clinical data. Expert Opin Investig Drugs. 2016 Mar 3